The nature of the link between obesity and diabetes

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Can obesity cause diabetes or cardiovascular disease? And if not, how are they related? These are questions looking for answers, and a small piece of the puzzle fell into place last week. A new systematic review and meta-analysis, published in JAMA Network Open, is the first-ever meta-analysis pooling data from studies conducted with a technique called Mendelian randomization which employs genetic markers and number crunching to mimic a clinical trial. Cleveland Clinic Newsroom: Cleveland Clinic genetic analysis links obesity with diabetes, coronary artery disease Mendelian randomizations are less reliable evidence of causation than randomized clinical trials, but they are much less expensive to conduct, and are better evidence than observational studies. The study authors explain: Mendelian randomization offers an opportunity to study associations without many of the typical biases that are inherent in traditional epidemiologic approaches. Thus, Mendelian randomization can fill...
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The nature of the link between obesity and diabetes was originally posted by Ketogenic Diet