Autophagy – a cure for many present-day diseases?

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Autophagy, a cellular cleaning process, gets activated in response to certain types of metabolic stress, including nutrient deprivation, growth factor depletion and hypoxia. Even without adequate circulation, each cell may break down sub-cellular parts and recycle those into new proteins or energy as required to survive. This explains why mTOR and autophagy are seen in every organism from yeast to humans. Studies on mutations of animals as varied as yeast, slime molds, plants and mice show that deletions of autophagy-related genes (ATG) in animals is largely incompatible with life. That is, most life on earth cannot survive without autophagy. Insulin and amino acids (through mTOR) are the main regulators of ATGs. These also happen to be two of our most basic nutrient sensors. When we eat carbohydrates, insulin goes up. When we eat protein, both insulin and mTOR go up. When nutrient sensors sense, well, nutrients, we signal our body to grow bigger, not to get smaller. Thus...
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Autophagy – a cure for many present-day diseases? was originally posted by Ketogenic Diet